Everything about Naked Dna totally explained
Naked DNA is
histone-free
DNA that's passed from cell to cell during a gene transfer process called
transformation or
transfection. In transformation, purified or naked DNA is taken up by the recipient cell which will give the recipient cell a new characteristic or
phenotype. Transfection differs from transformation since the DNA isn't generally incorporated into the cell's genome, it's only transiently expressed.
In the field of DNA vaccines or genetic immunization, the term "naked DNA" was coined by Vical to mean DNA delivered free from agents which promote transfection.
Research on the use of naked DNA for
DNA vaccinations and
gene therapy has shown some initial success, but have not yet resulted in any generally available therapy.
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